Vall d'Hebron Talks by VHIR 'p38 signalling in inflammation and colon cancer'

Speaker: Dr. Ana Cuenda, researcher at the National Center of Biotechnology, Madrid

Abstract: p38MAPK pathways are central to inflammatory processes.  The p38MAPK group has four members encoded by different genes, p38α, p38β, p38γ and p38δ.  While the roles of the p38α isoform have been widely studied in the context of inflammation and tumour development, the knowledge of the in vivo role of p38γ and p38δ in these processes is still very limited.  Our laboratory studies essential functions of these two less studied alternative p38MAPKs, in vivo and in cultured cells. This strategy has led to the discovery of unexpected cross talk between p38γ/p38δ and ERK1/2 pathway controlling cytokine production in cells during inflammation. The regulation of inflammatory processes by p38γ/p38δ has an impact in the development of different diseases such as colon and skin inflammation, arthritis, or colon cancer associated to colitis. We will discuss how, in specific settings, the p38MAPK components, p38γ and p38δ, operate in inflammatory processes, and the mechanisms underlying these unexpected functions.

Host:  Dr. José Miguel Lizcano De Vega, Protein kinases in cancer research (VHIR)

Register here to attend by Zoom https://gencat.zoom.us/j/92726233337