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Speaker: Dr. Mihalis S. Lionakis, Senior Investigator, Deputy Chief, Laboratory of Clinical Immunology & Microbiology (LCIM) - Chief, Fungal Pathogenesis Section, LCIM
National Institute of Allergy & Infectious Diseases (NIAID), NIH
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a life-threatening monogenic multiorgan autoimmune syndrome caused by AIRE deficiency that impairs central immune tolerance. In this lecture, Dr. Lionakis will discuss findings from the prospective clinical and research evaluation of ~200 APECED patients enrolled at the NIH Clinical Center and corroborating mechanistic studies in the Aire-deficient mouse model. Collectively, these findings provide novel insights into redefined diagnostic criteria, immunopathogenesis, and targeted therapeutic intervention
Host: Dr. Pere Soler Palacín, Paediatric Infectious Diseases and Immunodeficiencies Unit, Children's Hospital and Woman's Hospital. Head of group, Infection and immunity in pediatric patients. Vall Hebron Institut de Recerca
Registre Online: https://gencat.zoom.us/j/92144038494
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