PR(AG)519/2025 “Exploring the epigenetic and environmental basis of externalising and internalising problems (EPI-ENVI)”

  • Research groups: Psychiatry
  • VHIR PI: Silvia Alemany Sierra
  • Sponsor: Vall d’Hebron University Hospital Foundation – Research Institute (VHIR)
  • For further information and exercise of GDPR rights: lopd@vhir.org o vhir.org

Synopsis:

Use of retrospective data for clinical research. This study aims to evaluate the association between DNA methylation patterns and externalising and internalising problems in 300 schoolchildren. Both agnostic approaches (whole-epigenome study) and targeted approaches will be employed. Furthermore, the study will examine whether environmental risk factors are associated with the identified methylation patterns and whether DNA methylation acts as a mediator between environmental factors and externalising and internalising problems, as well as potential differences between boys and girls.

The data processed for the research project are pseudonymised and do not allow direct identification of the data subject.

Data origin:

Research project “Impact of Neurodevelopmental Disorders on School Performance: Genes and Environment (INSchool)” (Ref: 2228-30/202228-31). PIs: Dr Marta Ribasés and Dr Mireia Pagerols. Approved by the CEIm (PR(AG)491-2022). Saliva and nucleic acid samples from the ISCII Registry will be used, held in the private collection of the Psychiatric Genetics Unit of VHIR C.0004942.

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