Webinar IRISCAT- Dra. Carolina Serena "Adipose tissue as immunological organ: interaction between adipose-derived stem cells and gut microbiota on chronic inflammatory diseases"

  Activitat online —
02/06/2021 -- From 16:00h to 17:00h
Organize :
Vall d'Hebron Institut de Recerca (VHIR)
Modality: Presencial
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Crohn’s disease is characterized by the expansion of mesenteric fat, also known as ‘‘creeping fat.’’ We explored the plasticity and immune properties of adipose-stem cells in the context of Crohn’s patients as potential key players in the development of creeping fat. Mesenteric adipose-stem cells from Crohn’s patients presented a more proliferative, inflammatory, invasive, and phagocytic phenotype than equivalent cells from healthy donors, irrespective of the clinical stage. Furthermore, we found that the inflammatory events that accounts Crohn’s disease alter DNA methylations of the adipose stem cells, influencing their anti-inflammatory and regenerative capacity. Finally, we demonstrated that mesenteric adipose tissue of Crohn’s patients is a bacterial reservoir, and it has a microbiome signature that is dependent on their clinical status. Interestingly, we studied Crohn’s patients from adipocentric point of view, that was poorly approached.

 CV: Carolina Serena es llicenciada en Biologia per la Universitat Autònoma de Barcelona. Doctora per la Universitat Rovira i Virgili (URV) el 2007. Va desenvolupar la seva etapa postdoctoral al Weastmead Millenium Institute de Sydney, Austràlia. Durant aquesta etapa va participar com a investigadora en el projecte internacional "Phylogeny as a Base for Molecular Identification of Pathogenic Fungi" i com a professora d'un postgrau a la Universitat de Sydney. Actualment, es investigadora sènior I3 (prèviament Investigadora Ramon y Cajal), en l’Institut d’Investigació Sanitària Pere Virgili (IISPV), Hospital Joan XXIII de Tarragona dins del grup de Diabetes i Malalties Metabòliques Associades (DIAMET).  La seva principal línia d’investigació és identificar els factors clau que intervenen en el desencadenament de la resposta immune innata del teixit adipós en la inflamació local o sistèmica en el context de l’obesitat i la malaltia de Crohn. Ha liderat un projecte associat al Ramon y Cajal, dos projectes FIS consecutius (PI15/00143 i PI18/00037) fruit dels quals ha sortit 1 patent (EP17382615.7.) i 5 publicacions en revistes de gran impacte en la seva àrea (destacant publicacions: com a primera autora/autora de corresponding: Serena C. Stem Cell Reports. 2017 Oct 10;9(4):1109-1123; Serena C. Clin Epigenetics. 2020 Apr 6;12(1):53). A més de dirigir la seva línia de recerca, la IP col·labora activament amb diverses línies del grup DIAMET, fruit de les quals han donat lloc a 7 publicacions d’alt índex d’impacte (destacant publicacions com: Serena C. ISME J. 2018 Jun;12(7):1642-1657 o Keiran N, Nat Immunol. 2019 May;20(5):581-592) i és co-inventora d’una patent del grup (PCT/EP2019/051157).


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