Master Seminar, Dr. Lluís Montoliu "Genetically modified animal models in biomedicine: from standard transgenics to CRISPR-edited mice"

09/10/2017 -- From 11:30h to 11:30h
Addressed to : Accés lliure
Organize :
Unitat de Comunicació i Imatge
Modality: Presencial
Share it:

The experimentation with transgenic animals has shown temporal and spatial variability in transgene expression mainly due to position effects, related to the insertion of the transgene in the host genome. In this regard, the study of mechanisms regulating faithful transgene expression is essential for the development of animal models by genetic manipulation and, at the same time, allows increasing our knowledge on the organisation and structure of eukaryotic expression domains.

The study of the mechanisms, both functional and structural, implicated in obtaining an adequate pattern of transgene expression goes beyond the tyrosinase model being of capital relevance in projects of animal biotechnology and gene therapy, in which optimal expression must be guaranteed. In this sense, our laboratory has developed several transgenic constructs based in artificial chromosomes (BACs and YACs) aiming to improve heterologous expression in transgenic animals. In collaboration with Prof. F. Valdivieso’s laboratory (CBMSO, Madrid) we are producing a new animal model for the Alzheimer’s disease using a transgenic mouse prepared with a new artificial chromosome containing the APP gene.

Subscribe to our newsletters and be a part of Vall d'Hebron Campus

Select the newsletter you want to receive:

By accepting these conditions, you are agreeing to the processing of your personal data for the provision of the services requested through this portal, and, if necessary, for any procedures required by the administrations or public bodies involved in this processing, and their subsequent inclusion in the aforementioned automated file. You may exercise your rights to access, rectification, cancellation or opposition by writing to, clearly stating the subject as "Exercising of Data Protection Rights".
Operated by: Vall d’Hebron University Hospital Foundation – Research Institute.
Purpose: Manage the user’s contact information.
Legitimisation: Express acceptance of the privacy policy.
Rights: To access, rectify, and delete personal information data, as well to the portability thereof and to limit and/or oppose their use.
Source: The interested party themselves.