Seminari de Recerca "BAF chromatin remodeler links epigenetics to neuroblastoma metastasis"

 
  1. Vall d'Hebron Institut de Recerca - VHIR (Edifici Collserola) - Edifici Collserola — See in map
02/11/2022
02/11/2022 -- From 12:00h to 13:00h
Organize :
Recerca Vall d'Hebron
Modality: Presencial
Share it:
BAF chromatin remodeler links epigenetics to neuroblastoma metastasis

Dr. Carlos Jiménez Jiménez, Childhood Cancer and Blood Disorders group.

Epigenetic programming during development is essential for the determination of cell lineages, and its alteration contributes to the initiation of embryonal tumors. In neuroblastoma, neural crest progenitors block their natural differentiation course into sympathoadrenergic cells, leading to an aggressive and metastatic pediatric cancer. The study of the epigenetic regulators responsible for oncogenic epigenomic networks is crucial to develop new epigenetic-based therapies against these tumors.

mSWI/SNF ATP-dependent chromatin remodeling complexes act genome-wide translating epigenetic signals into opened chromatin states. With the aim of understanding the role of mSWI/SNF complexes in the control of the oncogenic epigenomes of neuroblastoma, we carried out a functional characterization of these remodelers in neuroblastoma cells by proteomic, transcriptomic and chromatin accessibility approaches, discovering that only the structural disruption of BAF subtype complexes impairs proliferation by promoting cell cycle blockade. Genome-wide chromatin remodeling analysis coupled with whole transcriptome data revealed that BAF disruption results in the epigenetic repression of an extensive invasiveness-related expression program, involving integrins, cadherins and key mesenchymal regulators, thereby reducing extracellular matrix adhesion and invasion in vitro, together with a drastic inhibition of neuroblastoma metastasis initiation and growth in vivo.

We defined a novel ATPase-independent role for BAF complex in the maintenance of an epigenomic program that allows neuroblastoma invasiveness and metastasis, urging the development of new BAF pharmacological structural disruptors for its therapeutic exploitation in metastatic neuroblastoma.

Host: Dr. Miguel Segura, Childhood Cancer and Blood Disorders group.

Related activities

Jornada de Cáncer de cérvix localmente avanzado: Perspectivas en el manejo terapéutico

06/02/2023 - 09:00
Médicos especialistas y residentes de oncología radioterápica, oncología médica y ginecología, radiología y medicina nuclear, Enfermería, residentes especialistas de Física y Protección Radiológica .
More information

V Jornada Infección y Terapias biológicas

06/12/2023 - 09:00
Médicos (facultativos y residentes) y Farmacéuticos que pautan terapias biológicas
More information

Curso de Aspectos claves para mejorar la vacunación en migrantes recién llegado

Edificio ICS Balmes C/ Gran Vía de les Corts Catalanes, 587, C/ de Balmes, 20. CP 08006, Barcelona
06/12/2023 - 16:00
Profesionales que trabajan con migrantes tanto en el ámbito sanitario como en lo social. Cómo: -Personas que trabajan en temas de Salud Pública tanto a nivel local como nacional -Personal que desarrolla sus funciones en centros de migrantes y centros de vacunación -Mediadores culturales -Trabajadores/as sociales -Personas que trabajan en áreas relacionadas con migración -Profesionales sanitarios (médicos; enfermeros/as; otros)
More information

Vacunas 2023 - XXVII Curso de Actualización en Inmunizaciones (presencial y virtual)

09/14/2023 - 09:00
More information

Subscribe to our newsletters and be a part of Vall d'Hebron Campus

Select the newsletter you want to receive:

By accepting these conditions, you are agreeing to the processing of your personal data for the provision of the services requested through this portal, and, if necessary, for any procedures required by the administrations or public bodies involved in this processing, and their subsequent inclusion in the aforementioned automated file. You may exercise your rights to access, rectification, cancellation or opposition by writing to web@vhebron.net, clearly stating the subject as "Exercising of Data Protection Rights".
Operated by: Vall d’Hebron University Hospital Foundation – Research Institute.
Purpose: Manage the user’s contact information.
Legitimisation: Express acceptance of the privacy policy.
Rights: To access, rectify, and delete personal information data, as well to the portability thereof and to limit and/or oppose their use.
Source: The interested party themselves.